SmartFTP can't connect to remote server

I can't get SmartFTP to connect to my remote server so that I can upload my files. I have tried everything to disabling my McAfee Antivirus and Windows firewall, etc. I am using Windows Vista. My subscription is paid up until next July, so that can't be the problem. I've even gone into the Windows tools section and tried changing some settings around like either using the passive mode or not, either way I still can't connect. I recently got an email from SmartFTP asking me to upgrade to a newer version, which I did. That is about the timing of the problems I started having.....