File notification Error

I am a total novice at FTP! I know enough to get me into trouble and then some!

Could some wonderful person to whom I will be forever indebted advise me on setting up a file notification? I have gone to Tools/Settings/Email and entered all the information I think should be there, however, I keep getting the above error message, or in full, that the target machine is actively refusing it! Nasty piece of work that is!!!

I would appreciate anyone who can steer me in the right direction!!

Begging is so unbecoming!!