SmartFTP with Microsoft Proxy server (or ISA server)

These proxy servers request authentication in the form of an NTLM challenge-handshake. Is SmartFTP able to handle such an authentication? If it does, how does the proper configuration looks like?
(The proxy server has only port 80 open, and this should be used both for FTP and HTTP)

Is there still a demand for NTLM authentication for the proxy server (MS ISA Server 200x)?

Regards,
-Mat