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Mine does the same thing. Totally unable to upload my files. I also get a 500 error that says, "I won't open a connection at 66.218.65.242 (only to 66.81.221.94)" Then it says that the transfer failed.

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Mine does the same thing. Totally unable to upload my files. I also get a 500 error that says, "I won't open a connection at 66.218.65.242 (only to 66.81.221.94)" Then it says that the transfer failed.
I believe this is a different issue than Lic.FooFighter's. Have you checked "Force Server IP for PASV Mode" under Settings -> Connection (either in the global settings or favorite settings)? If so, try to uncheck it. Otherwise, please also post the complete connection log.