Connection Refused

Nothing has changed in the set up of the computer, and I actually used the program last night, however I tried tonight and I'm getting no where, meep! Here is the message I recieve:

[21:59:10] A connection attempt failed because the connected party did not properly respond after a period of time, or established connection failed because connected host has failed to respond.
[21:59:10] Cannot login waiting to retry (30s)...
[21:59:10] Client closed the connection.
[21:59:10] Active Help:

I use it for two different areas, 1&1 and a personal site through yahoo sbc. I've gone to the page that was suggested, however none of it applies. I only run one firewall and that is with xp, and even took it down to see if that would help and recieved the same error.